New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis.

Saini, Karan Singh; Ashraf, Raghib; Mandalapu, Dhanaraju; Das, Sharmistha; Siddiqui, Mohd Quadir; Dwivedi, Sonam; Sarkar, Jayanta; Sharma, Vishnu Lal; Konwar, Rituraj

Saini, Karan Singh; Ashraf, Raghib; Mandalapu, Dhanaraju; Das, Sharmistha; Siddiqui, Mohd Quadir; Dwivedi, Sonam; Sarkar, Jayanta; Sharma, Vishnu Lal; Konwar, Rituraj.

Afiliação

Saini KS; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Hamidullah; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Ashraf R; Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, India.
Mandalapu D; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.
Das S; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Siddiqui MQ; Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra, India.
Dwivedi S; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Sarkar J; Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, India.
Sharma VL; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Konwar R; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.

Mol Carcinog ; 56(4): 1266-1280, 2017 04.

Article em En | MEDLINE | ID: mdl-27813185

Assuntos

Antineoplásicos/química; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Neoplasias da Mama/tratamento farmacológico; Mama/efeitos dos fármacos; Curcumina/análogos & derivados; Curcumina/uso terapêutico; Animais; Antineoplásicos/farmacologia; Mama/metabolismo; Mama/patologia; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Curcumina/farmacologia; DNA/genética; DNA/metabolismo; Dano ao DNA/efeitos dos fármacos; Feminino; Humanos; Simulação de Acoplamento Molecular; Ratos; Triazóis/química; Triazóis/farmacologia; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

anti-cancer; apoptosis; breast cancer; cell cycle; curcumin mimic

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mama / Neoplasias da Mama / Apoptose / Curcumina / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Mol Carcinog Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia

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