A monoclonal antibody targeting the dimer interface of epidermal growth factor receptor (EGFR).

Guo, Tujing; Zhao, Lin; Zhang, Yawen; Liu, Guoqiang; Yao, Yuanhang; Li, Huangjin

Guo, Tujing; Zhao, Lin; Zhang, Yawen; Liu, Guoqiang; Yao, Yuanhang; Li, Huangjin.

Afiliação

Guo T; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Zhao L; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Zhang Y; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Liu G; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Yao Y; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Li H; Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: 1002304772@qq.com.

Immunol Lett ; 180: 39-45, 2016 12.

Article em En | MEDLINE | ID: mdl-27816480

Assuntos

Anticorpos Monoclonais/farmacologia; Antineoplásicos/farmacologia; Receptores ErbB/metabolismo; Animais; Apoptose/efeitos dos fármacos; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Dimerização; Feminino; Células HeLa; Humanos; Imunoglobulina G/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Anti-cancer; Dimer interface; Dimerization; EGFR; Monoclonal antibody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores ErbB / Anticorpos Monoclonais / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Immunol Lett Ano de publicação: 2016 Tipo de documento: Article

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