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Mapping human temporal and parietal neuronal population activity and functional coupling during mathematical cognition.
Daitch, Amy L; Foster, Brett L; Schrouff, Jessica; Rangarajan, Vinitha; Kasikçi, Itir; Gattas, Sandra; Parvizi, Josef.
Afiliação
  • Daitch AL; Laboratory of Behavioral and Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305; jparvizi@stanford.edu adaitch@stanford.edu.
  • Foster BL; Laboratory of Behavioral and Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Schrouff J; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030.
  • Rangarajan V; Laboratory of Behavioral and Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Kasikçi I; Department of Computer Science, University College London, London WC1E 6BT, United Kingdom.
  • Gattas S; Laboratory of Behavioral and Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
  • Parvizi J; Department of Psychology, University of California, Berkeley, CA 94720.
Proc Natl Acad Sci U S A ; 113(46): E7277-E7286, 2016 11 15.
Article em En | MEDLINE | ID: mdl-27821758
Brain areas within the lateral parietal cortex (LPC) and ventral temporal cortex (VTC) have been shown to code for abstract quantity representations and for symbolic numerical representations, respectively. To explore the fast dynamics of activity within each region and the interaction between them, we used electrocorticography recordings from 16 neurosurgical subjects implanted with grids of electrodes over these two regions and tracked the activity within and between the regions as subjects performed three different numerical tasks. Although our results reconfirm the presence of math-selective hubs within the VTC and LPC, we report here a remarkable heterogeneity of neural responses within each region at both millimeter and millisecond scales. Moreover, we show that the heterogeneity of response profiles within each hub mirrors the distinct patterns of functional coupling between them. Our results support the existence of multiple bidirectional functional loops operating between discrete populations of neurons within the VTC and LPC during the visual processing of numerals and the performance of arithmetic functions. These findings reveal information about the dynamics of numerical processing in the brain and also provide insight into the fine-grained functional architecture and connectivity within the human brain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Parietal / Lobo Temporal / Conceitos Matemáticos / Neurônios Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Parietal / Lobo Temporal / Conceitos Matemáticos / Neurônios Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article