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IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.
Drennan, S; D'Avola, A; Gao, Y; Weigel, C; Chrysostomou, E; Steele, A J; Zenz, T; Plass, C; Johnson, P W; Williams, A P; Packham, G; Stevenson, F K; Oakes, C C; Forconi, F.
Afiliação
  • Drennan S; Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • D'Avola A; Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Gao Y; Wessex Investigational Sciences Hub laboratory, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Weigel C; Division of Epigenomics and Cancer Risk Factors, The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Chrysostomou E; Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Steele AJ; Molecular Oncology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Zenz T; Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Plass C; Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
  • Johnson PW; Division of Epigenomics and Cancer Risk Factors, The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Williams AP; Medical Oncology, University Hospital Southampton National Health Service Trust, Southampton, UK.
  • Packham G; Wessex Investigational Sciences Hub laboratory, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Stevenson FK; Molecular Oncology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Oakes CC; Molecular Immunology Group, Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Forconi F; Division of Epigenomics and Cancer Risk Factors, The German Cancer Research Center (DKFZ), Heidelberg, Germany.
Leukemia ; 31(8): 1686-1694, 2017 08.
Article em En | MEDLINE | ID: mdl-27890932
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Leucemia Linfocítica Crônica de Células B / Interleucina-10 / Cadeias Pesadas de Imunoglobulinas / Metilação de DNA / Mutação Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Leucemia Linfocítica Crônica de Células B / Interleucina-10 / Cadeias Pesadas de Imunoglobulinas / Metilação de DNA / Mutação Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido