Identification of a cyclodextrin inclusion complex of antimicrobial peptide CM4 and its antimicrobial activity.
Food Chem
; 221: 296-301, 2017 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-27979206
ABSTRACT
Antibacterial peptide CM4 (ABP-CM4) is a natural product isolated from the silkworm Bombyx mori. It is a small cationic peptide with broad-spectrum activities against harmful microorganisms and may be used as a novel food preservative. However, ABP-CM4 lacks tertiary structure in water-like solutions, which makes it more susceptible to proteases and labile when exposed to air. In this study, ß-cyclodextrin (ß-CD) was chosen to form an inclusion complex with ABP-CM4, which enhanced the physical and chemical properties of ABP-CM4 but did not decrease its antibacterial activity. The storage stability and susceptibility to proteinases of ABP-CM4 were apparently improved under the protection of ß-CD. This technology could also be widely applied to other AMPs as an antimicrobial system to be used in the food industry.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Peptídeos Catiônicos Antimicrobianos
/
Beta-Ciclodextrinas
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Frutas
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Food Chem
Ano de publicação:
2017
Tipo de documento:
Article