Hepatitis viruses in Ethiopia: a systematic review and meta-analysis.
BMC Infect Dis
; 16(1): 761, 2016 12 19.
Article
em En
| MEDLINE
| ID: mdl-27993129
ABSTRACT
BACKGROUND:
The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic review and meta-analysis was to provide a clear and comprehensive estimation of viral hepatitis epidemiology and the potential clinical burdens in Ethiopia.METHODS:
A comprehensive literature search was carried out from five decades (1968-2015) published studies from biomedical databases; PubMed, Google scholar, Medline and Web of Science.RESULTS:
The overall pooled prevalence of hepatitis B virus (HBV) was 7.4% (95%CI 6.5-8.4). The pooled prevalence among subgroups showed 5.2% (95%CI 3.7-7.4) in human immunodeficiency virus (HIV) infected individuals, 8.0% (95%CI 5.9-10.7) in community based studies, 8.4% (95%CI 5.4-12.7) in blood donors, 11.0% (95%CI 7.5-15.9) in immigrants and 6.9% (95%CI 5.6-8.5) in other groups. Among study parameters considered during meta-regression analysis, only study years were associated with a decreasing HBV prevalence rate over time. The overall pooled prevalence of anti-hepatitis C virus antibody (anti-HCV) was 3.1% (95%CI 2.2-4.4). Unlike HBV, the anti-HCV prevalence in HIV infected individuals was higher (5.5%, 95%CI 3.8-7.8%, p = 0.01) than the prevalence observed in the other subgroup of study population. Although relatively few data were available, hepatitis virus A (HAV), D (HDV) and E (HEV) were also circulated in Ethiopia.CONCLUSIONS:
This review indicates that all types of viral hepatitis origins are endemic in Ethiopia. Adapting a recommended diagnostic and treatment algorithm of viral hepatitis in the routine healthcare systems and implementing prevention and control policies in the general population needs an urgent attention.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatite Viral Humana
Tipo de estudo:
Risk_factors_studies
/
Systematic_reviews
Limite:
Adolescent
/
Adult
/
Humans
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
BMC Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha