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High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Bahous, Renata H; Jadavji, Nafisa M; Deng, Liyuan; Cosín-Tomás, Marta; Lu, Jessica; Malysheva, Olga; Leung, Kit-Yi; Ho, Ming-Kai; Pallàs, Mercè; Kaliman, Perla; Greene, Nicholas D E; Bedell, Barry J; Caudill, Marie A; Rozen, Rima.
Afiliação
  • Bahous RH; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
  • Jadavji NM; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
  • Deng L; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
  • Cosín-Tomás M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain.
  • Lu J; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
  • Malysheva O; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA.
  • Leung KY; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Ho MK; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Pallàs M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain.
  • Kaliman P; Institute of Biomedical Investigation of Barcelona, Spanish National Research Council, Barcelona, Spain.
  • Greene NDE; Center for Mind and Brain, University of California Davis, Davis, CA, USA.
  • Bedell BJ; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Caudill MA; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Rozen R; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA.
Hum Mol Genet ; 26(5): 888-900, 2017 03 01.
Article em En | MEDLINE | ID: mdl-28069796
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilenotetra-Hidrofolato Redutase (NADPH2) / Ácido Fólico / Homocistinúria / Memória de Curto Prazo / Espasticidade Muscular Limite: Animals / Pregnancy Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilenotetra-Hidrofolato Redutase (NADPH2) / Ácido Fólico / Homocistinúria / Memória de Curto Prazo / Espasticidade Muscular Limite: Animals / Pregnancy Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá