OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency.

Ullrich, M; Weber, M; Post, A M; Popp, S; Grein, J; Zechner, M; Guerrero González, H; Kreis, A; Schmitt, A G; Üçeyler, N; Lesch, K-P; Schuh, K

Ullrich, M; Weber, M; Post, A M; Popp, S; Grein, J; Zechner, M; Guerrero González, H; Kreis, A; Schmitt, A G; Üçeyler, N; Lesch, K-P; Schuh, K.

Afiliação

Ullrich M; Institute of Physiology I, University of Wuerzburg, Wuerzburg, Germany.
Weber M; Institute of Physiology II, University of Frankfurt, Frankfurt am Main, Germany.
Post AM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Frankfurt am Main, Germany.
Popp S; Division of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition, Laboratory of Translational Neuroscience, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
Grein J; Division of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition, Laboratory of Translational Neuroscience, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
Zechner M; Institute of Physiology I, University of Wuerzburg, Wuerzburg, Germany.
Guerrero González H; Institute of Physiology I, University of Wuerzburg, Wuerzburg, Germany.
Kreis A; Institute of Physiology I, University of Wuerzburg, Wuerzburg, Germany.
Schmitt AG; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
Üçeyler N; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
Lesch KP; Department of Neurology, University of Wuerzburg, Wuerzburg, Germany.
Schuh K; Division of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition, Laboratory of Translational Neuroscience, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.

Mol Psychiatry ; 23(2): 444-458, 2018 02.

Article em En | MEDLINE | ID: mdl-28070119

Assuntos

Transtorno Obsessivo-Compulsivo/metabolismo; Transtorno Obsessivo-Compulsivo/patologia; Proteínas Repressoras/fisiologia; Tonsila do Cerebelo/metabolismo; Animais; Comportamento Compulsivo/metabolismo; Corpo Estriado/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/fisiologia; Fluoxetina/metabolismo; Sistema de Sinalização das MAP Quinases/fisiologia; Camundongos; Camundongos Knockout; Neurônios/metabolismo; Comportamento Obsessivo/fisiopatologia; Receptor trkB/fisiologia; Proteínas Repressoras/genética; Transdução de Sinais; Sinapses/metabolismo; Transmissão Sináptica/fisiologia; Tálamo/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Transtorno Obsessivo-Compulsivo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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