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Improved survival of anchorage-dependent cells in core-shell hydrogel microcapsules via co-encapsulation with cell-friendly microspheres.
Kim, In-Yong; Choi, Hyungsoo; Kim, Kyekyoon Kevin.
Afiliação
  • Kim IY; a Department of Electrical and Computer Engineering , University of Illinois , Urbana , IL , USA.
  • Choi H; b Micro and Nanotechnology Laboratory , University of Illinois , Urbana , IL , USA.
  • Kim KK; a Department of Electrical and Computer Engineering , University of Illinois , Urbana , IL , USA.
J Microencapsul ; 34(1): 57-62, 2017 Feb.
Article em En | MEDLINE | ID: mdl-28097929
In this study, we investigated the effect of intracapsular environment on the survival of anchorage-dependent cells (ADCs) encapsulated in alginate microcapsules with three different core structures, i.e. liquid, semi-liquid and microsphere-encapsulating semi-liquid core, using NIH 3T3 fibroblasts as an ADC model. For the latter, we fabricated poly (ɛ-caprolactone) microspheres and co-encapsulated them with the cells, to establish cell-substrate interactions in the capsule. The fibroblast cells co-encapsulated with the microspheres exhibited higher survival and growth than those without. This study provides a "proof of concept" for employing microspheres as a cell-friendly surface to establish intracapsular cell-substrate interactions thus prolonging the survival of encapsulated therapeutic ADCs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Hidrogel de Polietilenoglicol-Dimetacrilato / Alginatos / Fibroblastos Limite: Animals Idioma: En Revista: J Microencapsul Assunto da revista: FARMACIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Hidrogel de Polietilenoglicol-Dimetacrilato / Alginatos / Fibroblastos Limite: Animals Idioma: En Revista: J Microencapsul Assunto da revista: FARMACIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos