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Migraine Headache and Long-Term Cardiovascular Outcomes: An Extended Follow-Up of the Women's Ischemia Syndrome Evaluation.
Rambarat, Cecil A; Elgendy, Islam Y; Johnson, B Delia; Reis, Steven E; Thompson, Diane V; Sharaf, Barry L; Bittner, Vera; Sopko, George; Bairey Merz, C Noel; Pepine, Carl J; Ahmed, Bina.
Afiliação
  • Rambarat CA; Department of Medicine, University of Florida, Gainesville. Electronic address: cecil.rambarat@medicine.ufl.edu.
  • Elgendy IY; Division of Cardiovascular Disease, Department of Medicine, University of Florida, Gainesville.
  • Johnson BD; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
  • Reis SE; Department of Medicine, University of Pittsburgh, Pa.
  • Thompson DV; Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, Pa.
  • Sharaf BL; Rhode Island Hospital, Providence.
  • Bittner V; Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham.
  • Sopko G; Division of Heart and Vascular Diseases, National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Md.
  • Bairey Merz CN; Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, Calif.
  • Pepine CJ; Division of Cardiovascular Disease, Department of Medicine, University of Florida, Gainesville.
  • Ahmed B; Division of Cardiovascular Disease, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Am J Med ; 130(6): 738-743, 2017 06.
Article em En | MEDLINE | ID: mdl-28109970
BACKGROUND: The association between migraine headache and cardiovascular events has been inconsistent. This study determines the long-term risk of cardiovascular events among women with and without a history of migraine headache who were under evaluation for suspected myocardial ischemia in the Women's Ischemia Syndrome Evaluation (WISE). METHODS: The WISE is a National Heart, Lung and Blood Institute-sponsored prospective, multicenter study that aims to improve myocardial ischemia evaluation in women. A total of 936 women presenting with symptoms of myocardial ischemia underwent structured data collection and coronary angiography. Information pertaining to migraine headache was available in 917 women. All-cause mortality data were available on all women for a median of 9.5 years, and nonfatal cardiovascular event data were available on 888 women for a median of 6.5 years. RESULTS: A total of 224 (24.4%) women reported a history of migraine headache. Compared with women who did not report a history of migraine headache, women with a history of migraine headache had an increased adjusted risk of cardiovascular event (cardiovascular death, nonfatal myocardial infarction, heart failure, or stroke) (hazard ratio 1.83; 95% confidence interval, 1.22-2.75) at a median follow-up of 6.5 years. This result was driven mainly by a twofold increase in the risk of stroke (hazard ratio 2.33; 95% confidence interval, 1.16-4.68). CONCLUSION: Among women being evaluated for ischemic heart disease, those reporting a history of migraine headache had increased risk of future cardiovascular events on long-term follow-up. This risk was primarily driven by a more-than twofold increase in the risk of stroke.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Transtornos de Enxaqueca Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Am J Med Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Transtornos de Enxaqueca Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Am J Med Ano de publicação: 2017 Tipo de documento: Article