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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Siegel, Dustin; Hui, Hon C; Doerffler, Edward; Clarke, Michael O; Chun, Kwon; Zhang, Lijun; Neville, Sean; Carra, Ernest; Lew, Willard; Ross, Bruce; Wang, Queenie; Wolfe, Lydia; Jordan, Robert; Soloveva, Veronica; Knox, John; Perry, Jason; Perron, Michel; Stray, Kirsten M; Barauskas, Ona; Feng, Joy Y; Xu, Yili; Lee, Gary; Rheingold, Arnold L; Ray, Adrian S; Bannister, Roy; Strickley, Robert; Swaminathan, Swami; Lee, William A; Bavari, Sina; Cihlar, Tomas; Lo, Michael K; Warren, Travis K; Mackman, Richard L.
Afiliação
  • Siegel D; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Hui HC; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Doerffler E; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Clarke MO; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Chun K; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Zhang L; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Neville S; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Carra E; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Lew W; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Ross B; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Wang Q; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Wolfe L; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Jordan R; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Soloveva V; United States Army Medical Research Institute of Infectious Diseases (USAMRIID) , Frederick, Maryland 21702, United States.
  • Knox J; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Perry J; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Perron M; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Stray KM; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Barauskas O; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Feng JY; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Xu Y; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Lee G; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Rheingold AL; University of California-San Diego , San Diego, California 92093, United States.
  • Ray AS; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Bannister R; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Strickley R; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Swaminathan S; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Lee WA; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Bavari S; United States Army Medical Research Institute of Infectious Diseases (USAMRIID) , Frederick, Maryland 21702, United States.
  • Cihlar T; Gilead Sciences, Inc. , Foster City, California 94404, United States.
  • Lo MK; Centers for Disease Control and Prevention , Atlanta, Georgia 30333, United States.
  • Warren TK; United States Army Medical Research Institute of Infectious Diseases (USAMRIID) , Frederick, Maryland 21702, United States.
  • Mackman RL; Gilead Sciences, Inc. , Foster City, California 94404, United States.
J Med Chem ; 60(5): 1648-1661, 2017 03 09.
Article em En | MEDLINE | ID: mdl-28124907
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Fosfóricos / Ribonucleotídeos / Viroses / Pró-Fármacos / Doença pelo Vírus Ebola / Alanina / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Fosfóricos / Ribonucleotídeos / Viroses / Pró-Fármacos / Doença pelo Vírus Ebola / Alanina / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos