Dual-Function Polymeric HPMA Prodrugs for the Delivery of miRNA.

Peng, Zheng-Hong; Xie, Ying; Wang, Yan; Li, Jing; Oupický, David

Peng, Zheng-Hong; Xie, Ying; Wang, Yan; Li, Jing; Oupický, David.

Afiliação

Peng ZH; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.
Xie Y; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.
Wang Y; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.
Li J; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.
Oupický D; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198, United States.

Mol Pharm ; 14(5): 1395-1404, 2017 05 01.

Article em En | MEDLINE | ID: mdl-28134535

Assuntos

Metacrilatos/química; MicroRNAs/química; Pró-Fármacos/química; Piridinas/química; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Humanos; MicroRNAs/genética; Receptores CXCR4/antagonistas & inibidores; Receptores CXCR4/metabolismo

Palavras-chave

CXCR4 antagonist; miRNA delivery; polymeric prodrug; polyplexes; self-immolative linker

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pró-Fármacos / MicroRNAs / Metacrilatos Limite: Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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