Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats.
Am J Orthod Dentofacial Orthop
; 151(2): 363-371, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28153167
ABSTRACT
INTRODUCTION:
In this study, we aimed to examine the role of intermittent hypoxia (IH) in dentofacial morphologic changes in growing rats.METHODS:
Seven-week-old male rats were exposed to IH at 20 cycles per hour (nadir of 4% oxygen to peak of 21% oxygen) for 8 hours per day for 6 weeks. Control rats were exposed to normoxia (N). Maxillofacial growth was compared between the 2 groups by linear measurements on cephalometric radiographs. To examine the dental arch morphology, study models and microcomputed tomography images of the jaws were taken. Additionally, tongue size was measured.RESULTS:
The gonial angle and the ramus of the mandible were smaller in the IH group than in the N group, whereas the body weights were not different between the 2 groups. Morphometric analysis of the dentition showed a significantly wider mandibular dentition and narrower maxillary dentition in the IH than in the N group. The relative width (+4.2 %) and length (tongue apex to vallate papillae, +3.5 %) of the tongue to the mandible were significantly greater in the IH group than in the N group.CONCLUSIONS:
IH induced dentofacial morphologic discrepancies in growing rats.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Crescimento
/
Macroglossia
/
Mandíbula
/
Hipóxia
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Orthod Dentofacial Orthop
Assunto da revista:
ODONTOLOGIA
/
ORTODONTIA
Ano de publicação:
2017
Tipo de documento:
Article