Cytosolic sodium concentration regulates contractility of cardiac muscle.
Basic Res Cardiol
; 84 Suppl 1: 35-45, 1989.
Article
em En
| MEDLINE
| ID: mdl-2818459
ABSTRACT
The present chapter provides experimental evidence to show that intracellular Na+ concentration regulates cardiac contractility effectively by altering intracellular Ca2+ concentration via the Na-Ca exchange. This steep coupling between the Na+ and Ca2+ electrochemical gradients implies that a change in intracellular Na+ concentration is accompanied by a concomitant change in intracellular Ca2+ concentration (and, therefore, contractility). Under the physiologic conditions, each cardiac action potential alters intracellular Na+ concentration in a dynamic manner. Therefore, Na-Ca exchange can regulate cardiac contraction from a beat-to-beat basis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Contração Miocárdica
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Basic Res Cardiol
Ano de publicação:
1989
Tipo de documento:
Article