Dissociation of norepinephrine turnover from alpha-2 responses after clorgiline.
Clin Pharmacol Ther
; 43(1): 32-8, 1988 Jan.
Article
em En
| MEDLINE
| ID: mdl-2826065
ABSTRACT
Responses to intravenous clonidine, a possible central noradrenergic probe, were examined in patients with depression before and after treatment with clorgiline, a selective monoamine oxidase type A inhibitor. Pulse rate, mean arterial blood pressure, plasma norepinephrine, 3-methoxy-4-hydroxyphenylglycol, and growth hormone were measured. Clorgiline treatment (2.5 to 10 mg/day) produced a variable reduction in the hypotensive response to clonidine but did not influence heart rate or plasma norepinephrine responses. Clorgiline markedly reduced the urinary output of norepinephrine and metabolites, indicating a reduced turnover of norepinephrine. None of the measured parameters corresponded with clinical effect. These data suggest that any clorgiline-induced alterations in alpha 2-receptor function as measured by responses to clonidine are modest and highly variable. Furthermore, since the variable and inconsistent changes in alpha 2-receptor function are dissociated from the massive changes in norepinephrine metabolism, regulation of presynaptic alpha 2-receptors appears unlikely to mediate the effects of clorgiline in patients with depression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propilaminas
/
Transtorno Bipolar
/
Norepinefrina
/
Receptores Adrenérgicos alfa
/
Clonidina
/
Clorgilina
/
Transtorno Depressivo
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1988
Tipo de documento:
Article