Immunoproteomic identification and characterization of Ni<sup>2+</sup>-regulated proteins implicates Ni<sup>2+</sup> in the induction of monocyte cell death.

Jakob, Annika; Mussotter, Franz; Ohnesorge, Stefanie; Dietz, Lisa; Pardo, Julian; Haidl, Ian D; Thierse, Hermann-Josef

Immunoproteomic identification and characterization of Ni²⁺-regulated proteins implicates Ni²⁺ in the induction of monocyte cell death.

Jakob, Annika; Mussotter, Franz; Ohnesorge, Stefanie; Dietz, Lisa; Pardo, Julian; Haidl, Ian D; Thierse, Hermann-Josef.

Afiliação

Jakob A; Laboratory for Immunology and Proteomics, Department of Dermatology and University Medical Center Mannheim, University of Heidelberg, Mannheim 68167, Germany.
Mussotter F; German Federal Institute for Risk Assessment, Chemicals and Product Safety, Berlin 10589, Germany.
Ohnesorge S; Laboratory for Immunology and Proteomics, Department of Dermatology and University Medical Center Mannheim, University of Heidelberg, Mannheim 68167, Germany.
Dietz L; Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology and Epigenetics, Freiburg 79108, Germany.
Pardo J; Laboratory for Immunology and Proteomics, Department of Dermatology and University Medical Center Mannheim, University of Heidelberg, Mannheim 68167, Germany.
Haidl ID; Functional Proteome Analysis, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Thierse HJ; Aragón I+D Foundation (ARAID), Zaragoza, Spain.

Cell Death Dis ; 8(3): e2684, 2017 03 16.

Article em En | MEDLINE | ID: mdl-28300831

Assuntos

Morte Celular/efeitos dos fármacos; Monócitos/efeitos dos fármacos; Níquel/farmacologia; Proteoma/metabolismo; Apoptose/efeitos dos fármacos; Caspase 3/metabolismo; Caspase 7/metabolismo; Núcleo Celular/efeitos dos fármacos; Núcleo Celular/metabolismo; Células Cultivadas; Células Dendríticas/efeitos dos fármacos; Células Dendríticas/metabolismo; Humanos; Inflamação/metabolismo; Monócitos/metabolismo; Proteômica/métodos; Linfócitos T/efeitos dos fármacos; Linfócitos T/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Morte Celular / Proteoma / Níquel Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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