Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.

Zhao, Xinbin; Sun, Kun; Lan, Zhou; Song, Wenxin; Cheng, Lili; Chi, Wenna; Chen, Jing; Huo, Yi; Xu, Lina; Liu, Xiaohui; Deng, Haiteng; Siegenthaler, Julie A; Chen, Ligong

Zhao, Xinbin; Sun, Kun; Lan, Zhou; Song, Wenxin; Cheng, Lili; Chi, Wenna; Chen, Jing; Huo, Yi; Xu, Lina; Liu, Xiaohui; Deng, Haiteng; Siegenthaler, Julie A; Chen, Ligong.

Afiliação

Zhao X; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Sun K; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Lan Z; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Song W; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Cheng L; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Chi W; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Chen J; Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.
Huo Y; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Xu L; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Liu X; Technology Center for Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Deng H; Technology Center for Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Siegenthaler JA; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Chen L; Department of Pediatrics, Denver-Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.

Sci Rep ; 7: 46344, 2017 04 11.

Article em En | MEDLINE | ID: mdl-28397817

Assuntos

Adenina/análogos & derivados; Fármacos Anti-HIV/efeitos adversos; Proteínas de Choque Térmico HSP90/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Organofosfonatos/efeitos adversos; Succinato Desidrogenase/metabolismo; Tenofovir/efeitos adversos; Adenina/efeitos adversos; Animais; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Glucose/metabolismo; Glicólise/efeitos dos fármacos; Proteínas de Choque Térmico HSP90/genética; Humanos; Nefropatias/etiologia; Nefropatias/metabolismo; Nefropatias/patologia; Camundongos; Mitocôndrias/genética; Modelos Biológicos; Proteoma; Proteômica; Succinato Desidrogenase/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinato Desidrogenase / Adenina / Proteínas de Choque Térmico HSP90 / Fármacos Anti-HIV / Organofosfonatos / Tenofovir / Mitocôndrias Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google