Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease.
Biochim Biophys Acta Mol Cell Res
; 1864(11 Pt A): 2001-2014, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28435009
ABSTRACT
The focus of this article is to highlight novel inhibitors and current examples where the use of selective small-molecule inhibitors has been critical in defining the roles of matrix metalloproteinases (MMPs) in disease. Selective small-molecule inhibitors are surgical chemical tools that can inhibit the targeted enzyme; they are the method of choice to ascertain the roles of MMPs and complement studies with knockout animals. This strategy can identify targets for therapeutic development as exemplified by the use of selective small-molecule MMP inhibitors in diabetic wound healing, spinal cord injury, stroke, traumatic brain injury, cancer metastasis, and viral infection. This article is part of a Special Issue entitled Matrix Metalloproteinases edited by Rafael Fridman.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
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Viroses
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Animais Geneticamente Modificados
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Acidente Vascular Cerebral
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Metaloproteinases da Matriz
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Lesões Encefálicas Traumáticas
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Proteínas de Neoplasias
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biochim Biophys Acta Mol Cell Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos