Role of the low-selective organic anion transport in regulation of osmotic balance of renal collecting duct principal cells under hypo-osmotic conditions.
Dokl Biol Sci
; 473(1): 43-45, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28508198
ABSTRACT
In the course of adaptation of the rat kidney collecting duct cells to hypo-osmotic medium, the organic anion transporter inhibitor probenecid reduced significantly the regulatory cell volume decrease in response to a hypotonic shock. Both probenecid and hypotonic shock delayed significantly the entry into a cell of the fluorescent dye calcein, which exists as anion at neutral pH. Thus, the organic osmolyte transport plays an important role in the regulatory decrease of the principal cell volume under the hypo-osmotic conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Osmótica
/
Equilíbrio Hidroeletrolítico
/
Rim
/
Túbulos Renais Coletores
Limite:
Animals
Idioma:
En
Revista:
Dokl Biol Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Federação Russa