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Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Liu, Peng; Ji, Yaoting; Yuen, Tony; Rendina-Ruedy, Elizabeth; DeMambro, Victoria E; Dhawan, Samarth; Abu-Amer, Wahid; Izadmehr, Sudeh; Zhou, Bin; Shin, Andrew C; Latif, Rauf; Thangeswaran, Priyanthan; Gupta, Animesh; Li, Jianhua; Shnayder, Valeria; Robinson, Samuel T; Yu, Yue Eric; Zhang, Xingjian; Yang, Feiran; Lu, Ping; Zhou, Yu; Zhu, Ling-Ling; Oberlin, Douglas J; Davies, Terry F; Reagan, Michaela R; Brown, Aaron; Kumar, T Rajendra; Epstein, Solomon; Iqbal, Jameel; Avadhani, Narayan G; New, Maria I; Molina, Henrik; van Klinken, Jan B; Guo, Edward X; Buettner, Christoph; Haider, Shozeb; Bian, Zhuan; Sun, Li; Rosen, Clifford J; Zaidi, Mone.
Afiliação
  • Liu P; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Ji Y; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Yuen T; School and Hospital of Stomatology, Wuhan University, and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, Hubei 430079, China.
  • Rendina-Ruedy E; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • DeMambro VE; Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
  • Dhawan S; Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
  • Abu-Amer W; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Izadmehr S; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Zhou B; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Shin AC; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Latif R; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Thangeswaran P; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Gupta A; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Li J; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Shnayder V; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Robinson ST; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Yu YE; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Zhang X; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Yang F; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Lu P; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Zhou Y; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Zhu LL; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Oberlin DJ; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Davies TF; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Reagan MR; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Brown A; Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
  • Kumar TR; Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
  • Epstein S; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
  • Iqbal J; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Avadhani NG; Pathology Service, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, California 90073, USA.
  • New MI; Deparment of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA.
  • Molina H; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • van Klinken JB; Proteomics Resource Center, Rockefeller University, New York, New York 10065, USA.
  • Guo EX; Department of Human Genetics and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2311 EZ Leiden, The Netherlands.
  • Buettner C; Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
  • Haider S; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Bian Z; Department of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London WC1N 1AX, UK.
  • Sun L; School and Hospital of Stomatology, Wuhan University, and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, Hubei 430079, China.
  • Rosen CJ; Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Zaidi M; Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Nature ; 546(7656): 107-112, 2017 06 01.
Article em En | MEDLINE | ID: mdl-28538730
ABSTRACT
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the ß-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the ß-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Termogênese / Subunidade beta do Hormônio Folículoestimulante / Adiposidade Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Termogênese / Subunidade beta do Hormônio Folículoestimulante / Adiposidade Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos