Case report of a primary effusion lymphoma successfully treated with oral valganciclovir after failing chemotherapy.
Hematol Oncol
; 36(1): 316-319, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-28580733
ABSTRACT
Primary effusion lymphoma is a rare non-Hodgkin lymphoma that presents with pleural effusions and lacking of tumour mass. It is universally associated with human herpesvirus 8 (HHV8) and is more frequent among immunosuppressed patients. There is no standard treatment, chemotherapy and anti-HIV therapy have been used with poor results, but there is still no strong evidence supporting the use of valganciclovir. We present the case of a HIV positive man that presented with pleural effusion compatible with primary effusion lymphoma and positivity for HHV8 DNA in blood. Bortezomib-containing treatment protocol was started, but the disease progressed within the chemotherapy. Therefore, treatment with oral valganciclovir was decided and the patient achieved a sustained radiological complete response. HHV8 DNA turned negative 6 months after starting the treatment with valganciclovir.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ganciclovir
/
Linfoma de Efusão Primária
Tipo de estudo:
Guideline
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hematol Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha