Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis.
J Immunol Res
; 2017: 7047201, 2017.
Article
em En
| MEDLINE
| ID: mdl-28584821
ABSTRACT
BACKGROUND:
The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood.METHODS:
We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge.RESULTS:
DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis.CONCLUSIONS:
The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
/
Linfócitos T Reguladores
/
Células Th17
/
Equilíbrio Th1-Th2
Limite:
Animals
Idioma:
En
Revista:
J Immunol Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China