Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.

Meyer, Stefan; Stevens, Adam; Paredes, Roberto; Schneider, Marion; Walker, Michael J; Williamson, Andrew J K; Gonzalez-Sanchez, Maria-Belen; Smetsers, Stephanie; Dalal, Vineet; Teng, Hsiang Ying; White, Daniel J; Taylor, Sam; Muter, Joanne; Pierce, Andrew; de Leonibus, Chiara; Rockx, Davy A P; Rooimans, Martin A; Spooncer, Elaine; Stauffer, Stacey; Biswas, Kajal; Godthelp, Barbara; Dorsman, Josephine; Clayton, Peter E; Sharan, Shyam K; Whetton, Anthony D

Meyer, Stefan; Stevens, Adam; Paredes, Roberto; Schneider, Marion; Walker, Michael J; Williamson, Andrew J K; Gonzalez-Sanchez, Maria-Belen; Smetsers, Stephanie; Dalal, Vineet; Teng, Hsiang Ying; White, Daniel J; Taylor, Sam; Muter, Joanne; Pierce, Andrew; de Leonibus, Chiara; Rockx, Davy A P; Rooimans, Martin A; Spooncer, Elaine; Stauffer, Stacey; Biswas, Kajal; Godthelp, Barbara; Dorsman, Josephine; Clayton, Peter E; Sharan, Shyam K; Whetton, Anthony D.

Afiliação

Meyer S; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Stevens A; Manchester Academic Health Science Centre, Manchester, UK.
Paredes R; Department of Paediatric and Adolescent Oncology, Royal Manchester Children's Hospital, Manchester, UK.
Schneider M; Young Oncology Unit, Christie Hospital, Manchester, UK.
Walker MJ; Manchester Academic Health Science Centre, Manchester, UK.
Williamson AJK; Department of Paediatric Endocrinology, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Gonzalez-Sanchez MB; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Smetsers S; Manchester Academic Health Science Centre, Manchester, UK.
Dalal V; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Teng HY; Manchester Academic Health Science Centre, Manchester, UK.
White DJ; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Taylor S; Manchester Academic Health Science Centre, Manchester, UK.
Muter J; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Pierce A; Manchester Academic Health Science Centre, Manchester, UK.
de Leonibus C; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Rockx DAP; Manchester Academic Health Science Centre, Manchester, UK.
Rooimans MA; Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, The Netherlands.
Spooncer E; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Stauffer S; Manchester Academic Health Science Centre, Manchester, UK.
Biswas K; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Godthelp B; Manchester Academic Health Science Centre, Manchester, UK.
Dorsman J; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Clayton PE; Manchester Academic Health Science Centre, Manchester, UK.
Sharan SK; Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.
Whetton AD; Manchester Academic Health Science Centre, Manchester, UK.

Cell Death Dis ; 8(6): e2875, 2017 06 15.

Article em En | MEDLINE | ID: mdl-28617445

Assuntos

Processamento Alternativo; Proteína BRCA2/genética; Proteína BRCA2/metabolismo; Resistencia a Medicamentos Antineoplásicos; Genes BRCA2; Mutação; Animais; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Dano ao DNA; Éxons; Anemia de Fanconi/tratamento farmacológico; Anemia de Fanconi/genética; Anemia de Fanconi/metabolismo; Feminino; Predisposição Genética para Doença; Humanos; Íntrons; Células K562; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/metabolismo; Camundongos; Recidiva Local de Neoplasia; Neoplasias Ovarianas/tratamento farmacológico; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Fenótipo; Splicing de RNA; Transcrição Gênica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento Alternativo / Resistencia a Medicamentos Antineoplásicos / Proteína BRCA2 / Genes BRCA2 / Mutação Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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