A Bright Future for Antibiotics?
Annu Rev Biochem
; 86: 567-583, 2017 06 20.
Article
em En
| MEDLINE
| ID: mdl-28654325
ABSTRACT
Multidrug resistance is a global threat as the clinically available potent antibiotic drugs are becoming exceedingly scarce. For example, increasing drug resistance among gram-positive bacteria is responsible for approximately one-third of nosocomial infections. As ribosomes are a major target for these drugs, they may serve as suitable objects for novel development of next-generation antibiotics. Three-dimensional structures of ribosomal particles from Staphylococcus aureus obtained by X-ray crystallography have shed light on fine details of drug binding sites and have revealed unique structural motifs specific for this pathogenic strain, which may be used for the design of novel degradable pathogen-specific, and hence, environmentally friendly drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribossomos
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Staphylococcus aureus
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Proteínas de Bactérias
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Desenho de Fármacos
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Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2017
Tipo de documento:
Article