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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.
Richner, Justin M; Jagger, Brett W; Shan, Chao; Fontes, Camila R; Dowd, Kimberly A; Cao, Bin; Himansu, Sunny; Caine, Elizabeth A; Nunes, Bruno T D; Medeiros, Daniele B A; Muruato, Antonio E; Foreman, Bryant M; Luo, Huanle; Wang, Tian; Barrett, Alan D; Weaver, Scott C; Vasconcelos, Pedro F C; Rossi, Shannan L; Ciaramella, Giuseppe; Mysorekar, Indira U; Pierson, Theodore C; Shi, Pei-Yong; Diamond, Michael S.
Afiliação
  • Richner JM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Jagger BW; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Shan C; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Fontes CR; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Dowd KA; Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD USA.
  • Cao B; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
  • Himansu S; Valera LLC, a Moderna Venture, 500 Technology Square, Cambridge, MA, USA.
  • Caine EA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Nunes BTD; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará State, Brazil.
  • Medeiros DBA; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará State, Brazil.
  • Muruato AE; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
  • Foreman BM; Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD USA.
  • Luo H; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
  • Wang T; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA.
  • Barrett AD; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA.
  • Weaver SC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA.
  • Vasconcelos PFC; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará State, Brazil; Department of Pathology, Pará State University, Belém, Brazil.
  • Rossi SL; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Ciaramella G; Valera LLC, a Moderna Venture, 500 Technology Square, Cambridge, MA, USA.
  • Mysorekar IU; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Pierson TC; Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD USA. Electronic address: piersontc@niaid.nih.gov.
  • Shi PY; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Translational Science, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA
  • Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M
Cell ; 170(2): 273-283.e12, 2017 Jul 13.
Article em En | MEDLINE | ID: mdl-28708997
ABSTRACT
The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus. Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise. As modified mRNA and live-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further development in humans to prevent congenital ZIKV syndrome is warranted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Virais / Zika virus / Infecção por Zika virus Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Virais / Zika virus / Infecção por Zika virus Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos