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Profilin, a Change in the Paradigm.
Rodríguez Del Río, P; Díaz-Perales, A; Sánchez-García, S; Escudero, C; Ibáñez, M D; Méndez-Brea, P; Barber, D.
Afiliação
  • Rodríguez Del Río P; Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
  • Díaz-Perales A; Health Research Institute Princesa, Madrid, Spain.
  • Sánchez-García S; Center for Plant Biotechnology and Genomics (UPM-INIA), Pozuelo de Alarcon, Madrid, Spain.
  • Escudero C; Department of Biotechnology and Plant Biology, ETSIAAB, Technical University of Madrid, Spain.
  • Ibáñez MD; Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
  • Méndez-Brea P; Health Research Institute Princesa, Madrid, Spain.
  • Barber D; Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Article em En | MEDLINE | ID: mdl-28760720
ABSTRACT
Profilin is a protein that is present in all eukaryotic cells and is responsible for cross-reactivity between pollen, latex, and plant foods. It has been classically acknowledged as a minor or nearly irrelevant allergen, although recent data are changing this conception. The objective of this manuscript is to provide a comprehensive review of published data on the role of this ubiquitous allergen in pollen, latex, and plant food allergy. The patterns of recognition of this minor allergen follow a north-south gradient. Although present in all pollens and vegetables, profilin is significantly associated with allergy to grass pollen and to Cucurbitaceae fruits. Heb v 8, the latex profilin, is usually a marker of profilin allergy in plant food-allergic patients, although it has no clinical relevance in latex allergy. Sensitization to profilin jeopardizes the diagnosis of pollen allergy and selection of immunotherapy, and although component-resolved diagnosis can identify its impact, there are no tailored treatments available. In recent years, several new publications have shown how profilin should be taken into account and, under certain circumstances, considered a marker of severity, an allergen capable of inducing respiratory symptoms, and, in its natural purified form, a potential candidate for etiological treatment of food allergy. Current data on profilin strongly support the need for a shift in the previously accepted paradigm for this allergen. More research should be done to assess the real clinical impact of sensitization in specific populations and to develop therapeutic strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Profilinas Limite: Humans Idioma: En Revista: J Investig Allergol Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Profilinas Limite: Humans Idioma: En Revista: J Investig Allergol Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha