Reversibility of hemodynamic hypofrontality in schizophrenia.
J Cereb Blood Flow Metab
; 7(1): 9-12, 1987 Feb.
Article
em En
| MEDLINE
| ID: mdl-2879850
ABSTRACT
Regional cerebral blood flow (CBF) was studied in 51 young schizophrenics. A significant decrease of CBF was seen in frontal and prefrontal regions (hypofrontal pattern) in chronic patients whose disease had evolved for more than 2 years and who were in remission. This hypofrontal pattern was reversible, as it disappeared during exacerbation of the disease. In 10 patients who had not been treated with neuroleptics for several weeks, we found a dopaminergic hypersensitivity in the frontal lobes, as a weak dose of piribedil restored near-normal frontality. This may reflect either the role of neuroleptic washout or a primitive dopaminergic depletion, as proposed by some authors in the chronic form of schizophrenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Circulação Cerebrovascular
/
Lobo Frontal
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
1987
Tipo de documento:
Article