Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study.
J Biomed Opt
; 22(8): 1-10, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28823113
ABSTRACT
Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias Bucais
/
Carcinoma in Situ
/
Microscopia Confocal
/
Detecção Precoce de Câncer
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Biomed Opt
Assunto da revista:
ENGENHARIA BIOMEDICA
/
OFTALMOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá