Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial.
J Clin Periodontol
; 44(12): 1285-1293, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28836279
ABSTRACT
AIMS:
To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics. MATERIALS ANDMETHODS:
Peri-implantitis was surgically treated with or without Zithromax® in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol and intent-to-treat analyses were performed.RESULTS:
The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups was 1.7 mm (SD ± 1.1, 95% CI 1.1, 2.3, p < .001) and 1.6 mm (SD ± 1.5, 95% CI 0.8, 2,4, p < .001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level and microbial load. Successful treatment (per protocol PPD ≤ 5 mm, no BOP, no suppuration and no bone loss ≥0.5 mm) at 12 months in test and control groups was 7/15 (46.7%) and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment.CONCLUSIONS:
Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide 1-year clinical benefits in comparison with those only receiving open flap debridement.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retalhos Cirúrgicos
/
Peri-Implantite
/
Desbridamento Periodontal
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Clin Periodontol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Suécia