Experimental models of demyelination and remyelination. / Modelos experimentales de desmielinización-remielinización.
Neurologia (Engl Ed)
; 35(1): 32-39, 2020.
Article
em En, Es
| MEDLINE
| ID: mdl-28863829
ABSTRACT
INTRODUCTION:
Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary. DEVELOPMENT We reviewed the different in vitro and in vivo experimental models used in multiple sclerosis research. Concerning in vitro models, we analysed cell cultures and slice models. As for in vivo models, we examined such models of autoimmunity and inflammation as experimental allergic encephalitis in different animals and virus-induced demyelinating diseases. Furthermore, we analysed models of demyelination and remyelination, including chemical lesions caused by cuprizone, lysolecithin, and ethidium bromide; zebrafish; and transgenic models.CONCLUSIONS:
Experimental models provide a deeper understanding of the different pathogenic mechanisms involved in multiple sclerosis. Choosing one model or another depends on the specific aims of the study.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Desmielinizantes
/
Remielinização
/
Esclerose Múltipla
Limite:
Animals
/
Humans
Idioma:
En
/
Es
Revista:
Neurologia (Engl Ed)
Ano de publicação:
2020
Tipo de documento:
Article