Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
Cancer Lett
; 36(3): 247-52, 1987 Sep.
Article
em En
| MEDLINE
| ID: mdl-2888528
ABSTRACT
The purpose of this investigation was to determine whether mitogen-induced cell proliferation is as effective as compensatory cell proliferation in achieving initiation of carcinogenesis in rat liver. Male Wistar rats were injected with a single non-necrogenic dose of the hepatocarcinogen diethylnitrosamine (DENA) during the peak of DNA synthesis following the administration of the hepatic mitogen ethylene dibromide (EDB) or a necrogenic dose of CCl4. After subjecting the animals to a promoting procedure, the rats were sacrificed and the initiated hepatocytes were monitored as gamma-glutamyltranspeptidase (gamma-GT) positive foci. The results indicate that while DENA administration during compensatory cell proliferation results in the formation of GT positive foci, no enzyme-altered foci were produced when the carcinogen was given during liver hyperplasia induced by EDB, despite the fact that at the time of carcinogen administration, the extent of cell proliferation, as monitored by thymidine incorporation into DNA, was the same in both the groups.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dibrometo de Etileno
/
Divisão Celular
/
Hidrocarbonetos Bromados
/
Fígado
/
Neoplasias Hepáticas Experimentais
/
Mitógenos
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Itália