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Postprandial Glucose Surges after Extremely Low Carbohydrate Diet in Healthy Adults.
Kanamori, Koji; Ihana-Sugiyama, Noriko; Yamamoto-Honda, Ritsuko; Nakamura, Tomoka; Sobe, Chie; Kamiya, Shigemi; Kishimoto, Miyako; Kajio, Hiroshi; Kawano, Kimiko; Noda, Mitsuhiko.
Afiliação
  • Kanamori K; Nutrition Management Department, National Center for Global Health and Medicine Center Hospital.
  • Ihana-Sugiyama N; Nutrition Management Department, National Hospital Organization East Saitama National Hospital.
  • Yamamoto-Honda R; Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital.
  • Nakamura T; Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital.
  • Sobe C; Health Management Center, Toranomon Hospital.
  • Kamiya S; Department of Endocrinology and Metabolism, Toranomon Hospital.
  • Kishimoto M; Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital.
  • Kajio H; Nutrition Management Department, National Hospital Organization Chiba Medical Center.
  • Kawano K; Nutrition Management Department, National Center for Global Health and Medicine Center Hospital.
  • Noda M; Department of Internal Medicine, Sanno Hospital.
Tohoku J Exp Med ; 243(1): 35-39, 2017 09.
Article em En | MEDLINE | ID: mdl-28924074
Carbohydrate-restricted diets are prevalent not only in obese people but also in the general population to maintain appropriate body weight. Here, we report that extreme carbohydrate restriction for one day affects the subsequent blood glucose levels in healthy adults. Ten subjects (median age 30.5 years, BMI 21.1 kg/m2, and HbA1c 5.5%), wearing with a continuous glucose monitoring device, were given isoenergetic test meals for 4 consecutive days. On day 1, day 2 (D2), and day 4 (D4), they consumed normal-carbohydrate (63-66% carbohydrate) diet, while on day 3, they took low-carbohydrate/high-fat (5% carbohydrate) diet. The daily energy intake was 2,200 kcal for males and 1,700 kcal for females. On D2 and D4, we calculated the mean 24-hr blood glucose level (MEAN/24h) and its standard deviation (SD/24h), the area under the curve (AUC) for glucose over 140 mg/dL within 4 hours after each meal (AUC/4h/140), the mean amplitude of the glycemic excursions (MAGE), the incremental AUC of 24-hr blood glucose level above the mean plus one standard deviation (iAUC/MEAN+SD). Indexes for glucose fluctuation on D4 were significantly greater than those on D2 (SD/24h; p = 0.009, MAGE; p = 0.013, AUC/4h/140 after breakfast and dinner; p = 0.006 and 0.005, and iAUC/MEAN+SD; p = 0.007). The value of MEAN/24h and AUC/4h/140 after lunch on D4 were greater than those on D2, but those differences were not statistically significant. In conclusion, consumption of low-carbohydrate/high-fat diet appears to cause higher postprandial blood glucose on subsequent normal-carbohydrate diet particularly after breakfast and dinner in healthy adults.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde / Período Pós-Prandial / Dieta com Restrição de Carboidratos / Glucose Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Tohoku J Exp Med Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde / Período Pós-Prandial / Dieta com Restrição de Carboidratos / Glucose Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Tohoku J Exp Med Ano de publicação: 2017 Tipo de documento: Article