[Periodic respiration during sleep at high altitude. Effects of a hypnotic benzodiazepine, loprazolam]. / Respiration périodique pendant le sommeil en altitude. Effets d'une benzodiazépine hypnotique, le loprazolam.
Presse Med
; 17(10): 471-4, 1988 Mar 19.
Article
em Fr
| MEDLINE
| ID: mdl-2895461
ABSTRACT
Sleep and respiration studies were carried out in 12 subjects (9 males, 3 females) at an altitude of 4,800 metres, during effect of a French expedition in the Himalayas. The effect of loprazolam, a hypnotic benzodiazepine, was investigated in a double-blind, 2 parallel group, 1 mg loprazolam versus placebo trial. Sleep was evaluated by means of electroencephalographic recordings and questionnaires. The effects of altitude in each subject were intercurrent wakefulness increase, slow wave sleep and paradoxical sleep decrease and nocturnal periodic breathing. The mean duration of sleep apnea episodes was 12 seconds with a maximum of 24 seconds. These episodes occurred during stages 1 or 2 of sleep and during paradoxical sleep. Female subjects exhibited less periodic breathing than males. Acclimatization to high altitude increased total sleep time, stage 3 duration and percentage of paradoxical sleep. Loprazolam tended to decrease stage 2 latency and did not worsen slow wave sleep depression or episodes of apnea. Normal amounts of slow wave sleep and intrasleep wakefulness appeared in the loprazolam group after acclimatization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Respiratórios
/
Sono
/
Ansiolíticos
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Benzodiazepinas
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Benzodiazepinonas
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Doença da Altitude
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Hipóxia
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Fr
Revista:
Presse Med
Ano de publicação:
1988
Tipo de documento:
Article