In an in-vitro model using human fetal membranes, 17-&#945; hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening.

Kumar, Deepak; Moore, Robert M; Mercer, Brian M; Mansour, Joseph M; Mesiano, Sam; Schatz, Frederick; Lockwood, Charles J; Moore, John J

In an in-vitro model using human fetal membranes, 17-α hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening.

Kumar, Deepak; Moore, Robert M; Mercer, Brian M; Mansour, Joseph M; Mesiano, Sam; Schatz, Frederick; Lockwood, Charles J; Moore, John J.

Afiliação

Kumar D; Department of Pediatrics, Case Western Reserve University, Cleveland, OH.
Moore RM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH.
Mercer BM; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH.
Mansour JM; Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH.
Mesiano S; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH.
Schatz F; Department of Obstetrics and Gynecology, South Florida University, Tampa, FL.
Lockwood CJ; Department of Obstetrics and Gynecology, South Florida University, Tampa, FL.
Moore JJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH. Electronic address: jmoore@metrohealth.org.

Am J Obstet Gynecol ; 217(6): 695.e1-695.e14, 2017 12.

Article em En | MEDLINE | ID: mdl-29031893

Assuntos

Membranas Extraembrionárias/efeitos dos fármacos; Ruptura Prematura de Membranas Fetais/prevenção & controle; Hidroxiprogesteronas/farmacologia; Progestinas/farmacologia; Caproato de 17 alfa-Hidroxiprogesterona; Feminino; Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia; Hemostáticos/farmacologia; Humanos; Técnicas In Vitro; Modelos Biológicos; Gravidez; Nascimento Prematuro/prevenção & controle; Trombina/farmacologia; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

17-alpha hydroxyprogesterone caproate; biomechanical weakening; fetal membranes; granulocyte-macrophage colonystimulating factor; medroxyprogesterone acetate; preterm premature rupture of the fetal membranes; progesterone; progestogens; thrombin; tumor necrosis factor-alpha

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progestinas / Ruptura Prematura de Membranas Fetais / Membranas Extraembrionárias / Hidroxiprogesteronas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Ano de publicação: 2017 Tipo de documento: Article

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