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Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms.
Hobbs, Gabriela S; Hanasoge Somasundara, Amritha Varshini; Kleppe, Maria; Litvin, Rivka; Arcila, Maria; Ahn, Jihae; McKenney, Anna Sophia; Knapp, Kristina; Ptashkin, Ryan; Weinstein, Howard; Heinemann, Murk-Hein; Francis, Jasmine; Chanel, Suzanne; Berman, Ellin; Mauro, Michael; Tallman, Martin S; Heaney, Mark L; Levine, Ross L; Rampal, Raajit K.
Afiliação
  • Hobbs GS; Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, USA.
  • Hanasoge Somasundara AV; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA.
  • Kleppe M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA.
  • Litvin R; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA.
  • Arcila M; Department of Pathology, Memorial Sloan Kettering Cancer Center, USA.
  • Ahn J; Driskill Graduate Program in Life Sciences, Feinberg School of Medicine, Northwestern University, USA.
  • McKenney AS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA.
  • Knapp K; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, USA.
  • Ptashkin R; Center for Epigenetics Research Memorial Sloan Kettering Center, USA.
  • Weinstein H; Department of Pathology, Memorial Sloan Kettering Cancer Center, USA.
  • Heinemann MH; Cardiology Service, Department of Medicine Memorial Sloan Kettering Cancer Center, USA.
  • Francis J; Department of Surgery, Memorial Sloan Kettering Cancer Center, USA.
  • Chanel S; Department of Surgery, Memorial Sloan Kettering Cancer Center, USA.
  • Berman E; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA.
  • Mauro M; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA.
  • Tallman MS; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA.
  • Heaney ML; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA.
  • Levine RL; Department of Medicine, Columbia University Medical Center, USA.
  • Rampal RK; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA.
Haematologica ; 103(1): e5-e9, 2018 01.
Article em En | MEDLINE | ID: mdl-29051283
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esplenomegalia / Transdução de Sinais / Proteínas de Choque Térmico HSP90 / Fatores de Transcrição STAT / Janus Quinases / Transtornos Mieloproliferativos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esplenomegalia / Transdução de Sinais / Proteínas de Choque Térmico HSP90 / Fatores de Transcrição STAT / Janus Quinases / Transtornos Mieloproliferativos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos