Treatment of anxiety with ketazolam in elderly patients.
Clin Ther
; 10(5): 536-42, 1988.
Article
em En
| MEDLINE
| ID: mdl-2908803
ABSTRACT
In a multicenter, double-blind trial, 63 elderly patients who had experienced a generalized anxiety disorder for at least one month were randomly assigned to receive 15 mg of ketazolam (n = 31) or placebo (n = 32) daily for 15 days. At the end of this period, if their total scores on the Hamilton Anxiety Rating Scale had decreased by at least 25%, treatment was continued unchanged for a further 15 days. Patients who did not respond to treatment were given an additional 15 mg of ketazolam daily. During the initial 15 days, 83% of the ketazolam-treated patients and 43% of the placebo patients responded to treatment (P < 0.01). During the second 15-day period, the anxiety scores of the ketazolam-treated patients continued to decline significantly, whereas the placebo patients showed no improvement. According to the investigators' assessments of severity of anxiety and patients' ratings of treatment effectiveness, ketazolam was significantly superior to placebo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Ansiolíticos
/
Benzodiazepinas
/
Benzodiazepinonas
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Ther
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Itália