Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.

Zhang, Wei; Zhong, Biao; Zhang, Chi; Wang, Yukai; Guo, Shang; Luo, Congfeng; Zhan, Yulin

Zhang, Wei; Zhong, Biao; Zhang, Chi; Wang, Yukai; Guo, Shang; Luo, Congfeng; Zhan, Yulin.

Afiliação

Zhang W; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Zhong B; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: biao.zhong@139.com.
Zhang C; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Wang Y; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Guo S; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Luo C; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Zhan Y; Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Bioorg Chem ; 76: 13-22, 2018 02.

Article em En | MEDLINE | ID: mdl-29102725

Assuntos

Proteína ADAMTS4/metabolismo; Fragmentos de Peptídeos/metabolismo; Peptídeos Cíclicos/metabolismo; Inibidor Tecidual de Metaloproteinase-3/metabolismo; Proteína ADAMTS4/química; Sítios de Ligação; Entropia; Humanos; Simulação de Dinâmica Molecular; Fragmentos de Peptídeos/síntese química; Fragmentos de Peptídeos/química; Peptídeos Cíclicos/síntese química; Peptídeos Cíclicos/química; Ligação Proteica; Domínios Proteicos; Inibidor Tecidual de Metaloproteinase-3/síntese química; Inibidor Tecidual de Metaloproteinase-3/química

Palavras-chave

ADAMTS4; Conformational flexibility; Cyclization; Entropy penalty; Osteoarthritis; Peptide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos Cíclicos / Inibidor Tecidual de Metaloproteinase-3 / Proteína ADAMTS4 Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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