Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing.
Age Ageing
; 47(1): 95-100, 2018 01 01.
Article
em En
| MEDLINE
| ID: mdl-29106439
ABSTRACT
Background:
hypertension is a risk for brain ageing, but the mechanisms underlying this effect remain unclear. Magnetic resonance imaging (MRI) detected biomarkers of brain ageing include white matter hyperintensities (WMHs), a marker of cerebrovascular disease, and hippocampal volume, a marker of Alzheimer's disease pathology.Objective:
to examine relationships between blood pressure (BP) components and brain pathology in older adults.Subjects:
two hundred and twenty-seven members of the Aberdeen 1936 Birth Cohort between ages 64 and 68 years.Methods:
BP was assessed biennially between 64 and 68 years and brain MRI performed at 68 years. The risk factors of interest were diastolic and systolic BP and their visit-to-visit variability. Outcomes were WMH abundance and hippocampal volume. Regression models, controlling for confounding factors, examined their relationships.Results:
higher diastolic BP predicted increased WMH (ß = 0.13, P = 0.044) and smaller hippocampi (ß = -0.25, P = 0.006). In contrast, increased systolic BP predicted larger hippocampi (ß = 0.22, P = 0.013). Variability of diastolic BP predicted lower hippocampal volume (ß = -0.15, P = 0.033). These relationships were independent of confounding life-course risk factors. Anti-hypertensive medication did not modify these relationships, but was independently associated with increased WMH (ß = 0.17, P = 0.011).Conclusion:
increased diastolic BP is associated with biomarkers of both cerebrovascular and Alzheimer's diseases, whereas the role of systolic BP is less clear, with evidence for a protective effect on hippocampal volume. These differing relationships emphasise the importance of considering individual BP components with regard to brain ageing and pathology. Interventions targeting diastolic hypertension and its chronic variability may provide new strategies able to slow the accumulation of these harmful pathologies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Envelhecimento
/
Imageamento por Ressonância Magnética
/
Transtornos Cerebrovasculares
/
Leucoencefalopatias
/
Doença de Alzheimer
/
Substância Branca
/
Hipocampo
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Age Ageing
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido