Gene expression analysis reveals chronic low level exposure to the pesticide diazinon affects psychological disorders gene sets in the adult rat.

Savy, Claire Y; Fitchett, Ann E; Blain, Peter G; Morris, Christopher M; Judge, Sarah J

Savy, Claire Y; Fitchett, Ann E; Blain, Peter G; Morris, Christopher M; Judge, Sarah J.

Afiliação

Savy CY; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: c.savy@leeds.ac.uk.
Fitchett AE; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: Ann.Fitchett@newcastle.ac.uk.
Blain PG; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: Peter.Blain@newcastle.ac.uk.
Morris CM; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: C.M.Morris@newcastle.ac.uk.
Judge SJ; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address: Sarah.Judge@newcastle.ac.uk.

Toxicology ; 393: 90-101, 2018 01 15.

Article em En | MEDLINE | ID: mdl-29108742

Assuntos

Encéfalo/efeitos dos fármacos; Diazinon/toxicidade; Inseticidas/toxicidade; Transtornos Mentais/genética; Acetilcolinesterase/sangue; Acetilcolinesterase/metabolismo; Animais; Comportamento Animal; Encéfalo/metabolismo; Butirilcolinesterase/sangue; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/toxicidade; Proteínas da Membrana Plasmática de Transporte de Dopamina/genética; Expressão Gênica/efeitos dos fármacos; Glutaminase/genética; Masculino; Ratos; Receptores de AMPA/genética; Transmissão Sináptica; Tirosina 3-Mono-Oxigenase/genética

Palavras-chave

Anxiety; Dopamine; Glutamate; Organophosphate; Pesticide; Serotonin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Diazinon / Inseticidas / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Toxicology Ano de publicação: 2018 Tipo de documento: Article

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