Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation: limitations and benefits.
Reproduction
; 155(2): R105-R119, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29122969
ABSTRACT
Oocyte activation is a calcium (Ca2+)-dependent process that has been investigated in depth, in particular, regarding its impact on assisted reproduction technology (ART). Following a standard model of signal transduction, Ca2+ drives the meiotic progression upon fertilization in all species studied to date. However, Ca2+ changes during oocyte activation are species specific, and they can be classified in two modalities based on the pattern defined by the Ca2+ signature a single Ca2+ transient (e.g. amphibians) or repetitive Ca2+ transients called Ca2+ oscillations (e.g. mammals). Interestingly, assisted oocyte activation (AOA) methods have highlighted the ability of mammalian oocytes to respond to single Ca2+ transients with normal embryonic development. In this regard, there is evidence supporting that cellular events during the process of oocyte activation are initiated by different number of Ca2+ oscillations. Moreover, it was proposed that oocyte activation and subsequent embryonic development are dependent on the total summation of the Ca2+ peaks, rather than to a specific frequency pattern of Ca2+ oscillations. The present review aims to demonstrate the complexity of mammalian oocyte activation by describing the series of Ca2+-linked physiological events involved in mediating the egg-to-embryo transition. Furthermore, mechanisms of AOA and the limitations and benefits associated with the application of different activation agents are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Cálcio
/
Sinalização do Cálcio
/
Fertilização
/
Técnicas de Maturação in Vitro de Oócitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Reproduction
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Bélgica