ß-d-<i>N</i><sup>4</sup>-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.

Urakova, Nadya; Kuznetsova, Valeriya; Crossman, David K; Sokratian, Arpine; Guthrie, David B; Kolykhalov, Alexander A; Lockwood, Mark A; Natchus, Michael G; Crowley, Michael R; Painter, George R; Frolova, Elena I; Frolov, Ilya

ß-d-N⁴-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.

Urakova, Nadya; Kuznetsova, Valeriya; Crossman, David K; Sokratian, Arpine; Guthrie, David B; Kolykhalov, Alexander A; Lockwood, Mark A; Natchus, Michael G; Crowley, Michael R; Painter, George R; Frolova, Elena I; Frolov, Ilya.

Afiliação

Urakova N; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kuznetsova V; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Crossman DK; Heflin Center for Genomic Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Sokratian A; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Guthrie DB; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Kolykhalov AA; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Lockwood MA; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Natchus MG; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Crowley MR; Heflin Center for Genomic Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Painter GR; Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Frolova EI; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.
Frolov I; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA efrolova@uab.edu ivfrolov@uab.edu.

J Virol ; 92(3)2018 02 01.

Article em En | MEDLINE | ID: mdl-29167335

Assuntos

Alphavirus/patogenicidade; Antivirais/farmacologia; Citidina/análogos & derivados; Mutação; Alphavirus/efeitos dos fármacos; Alphavirus/genética; Animais; Linhagem Celular; Chlorocebus aethiops; Cricetinae; Citidina/farmacologia; Genoma Viral/efeitos dos fármacos; Humanos; Ribavirina/farmacologia; Células Vero; Carga Viral; Proteínas não Estruturais Virais/genética

Palavras-chave

N-hydroxycytidine; RNA-dependent RNA polymerase; Venezuelan equine encephalitis virus; alphaviruses; antivirals; drug-resistant mutant; lethal mutagenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Alphavirus / Citidina / Mutação Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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