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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Zhou, Yiming; Castonguay, Philip; Sidhom, Eriene-Heidi; Clark, Abbe R; Dvela-Levitt, Moran; Kim, Sookyung; Sieber, Jonas; Wieder, Nicolas; Jung, Ji Yong; Andreeva, Svetlana; Reichardt, Jana; Dubois, Frank; Hoffmann, Sigrid C; Basgen, John M; Montesinos, Mónica S; Weins, Astrid; Johnson, Ashley C; Lander, Eric S; Garrett, Michael R; Hopkins, Corey R; Greka, Anna.
Afiliação
  • Zhou Y; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Castonguay P; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sidhom EH; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Clark AR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dvela-Levitt M; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kim S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sieber J; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Wieder N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Jung JY; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Andreeva S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Reichardt J; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Dubois F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Hoffmann SC; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Basgen JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Montesinos MS; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Weins A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Johnson AC; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Lander ES; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
  • Garrett MR; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Hopkins CR; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Greka A; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Science ; 358(6368): 1332-1336, 2017 12 08.
Article em En | MEDLINE | ID: mdl-29217578
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteinúria / Glomerulosclerose Segmentar e Focal / Canais de Cátion TRPC / Hipertensão Renal / Indazóis Limite: Animals Idioma: En Revista: Science Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteinúria / Glomerulosclerose Segmentar e Focal / Canais de Cátion TRPC / Hipertensão Renal / Indazóis Limite: Animals Idioma: En Revista: Science Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos