A Coupled Ionization-Conformational Equilibrium Is Required To Understand the Properties of Ionizable Residues in the Hydrophobic Interior of Staphylococcal Nuclease.

Liu, Jinfeng; Swails, Jason; Zhang, John Z H; He, Xiao; Roitberg, Adrian E

Liu, Jinfeng; Swails, Jason; Zhang, John Z H; He, Xiao; Roitberg, Adrian E.

Afiliação

Liu J; School of Chemistry and Molecular Engineering, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University , Shanghai, 200062, China.
Swails J; Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.
Zhang JZH; Department of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, 210009, China.
He X; Department of Chemistry and Chemical Biology and BioMaPS Institute, Rutgers University , Piscataway, New Jersey 08854, United States.
Roitberg AE; School of Chemistry and Molecular Engineering, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University , Shanghai, 200062, China.

J Am Chem Soc ; 140(5): 1639-1648, 2018 02 07.

Article em En | MEDLINE | ID: mdl-29308643

Assuntos

Nuclease do Micrococo/química; Concentração de Íons de Hidrogênio; Interações Hidrofóbicas e Hidrofílicas; Nuclease do Micrococo/metabolismo; Conformação Proteica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nuclease do Micrococo Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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