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Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals.
Mezzavilla, Massimo; Tomei, Sara; Alkayal, Fadi; Melhem, Motasem; Ali, Maisa M; Al-Arouj, Monira; Bennakhi, Abdullah; Alsmadi, Osama; Elkum, Naser.
Afiliação
  • Mezzavilla M; Out-Patient Clinic, 5th Floor, Sidra Medicine, Qatar Foundation, Al Luqta Street, Education City North Campus, PO Box 26999, Doha, Qatar.
  • Tomei S; Out-Patient Clinic, 5th Floor, Sidra Medicine, Qatar Foundation, Al Luqta Street, Education City North Campus, PO Box 26999, Doha, Qatar.
  • Alkayal F; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Melhem M; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Ali MM; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Al-Arouj M; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Bennakhi A; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Alsmadi O; Dasman Diabetes Institute, Jasim Mohamad Al Bahar St, Kuwait City, Kuwait.
  • Elkum N; King Hussein Cancer Center, Amman, Jordan.
J Transl Med ; 16(1): 20, 2018 01 30.
Article em En | MEDLINE | ID: mdl-29382345
BACKGROUND: Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have been conducted in European populations. Here we aimed to identify common genetic variants that affect vitamin D concentrations in individuals of self-reported Arab ethnicity. METHODS: The study included 1151 Arab subjects living in Kuwait. Common variants of single-nucleotide polymorphisms and genes previously associated with vitamin D levels, such as GC, PDE3B, CYP2R1, and NADSYN1, were genotyped. Raw vitamin D level data were corrected for age, body mass index, and sex and then normalized. Regression tree analyses were performed to identify the impact of genetic variants on vitamin D levels. RESULTS: Compared with other gene variants, the GC gene variants exhibited the greatest impact on vitamin D levels in our study population, of which rs2298850 had the lowest p value (0.003). Individuals homozygous for the derived allele C had lower vitamin D levels. Analyses of the interaction between the number of years for which the subjects had lived in Kuwait and genetic variation in the GC gene showed that those with the CC genotype of rs2298850 who had lived in Kuwait for < 51 years had a mean 25(OH)D level of 10 ng/ml, whereas those who were homozygous for the ancestral allele had a mean 25(OH)D level of 17 ng/ml. Furthermore, subjects who had lived in Kuwait for > 51 years had higher vitamin D levels (mean 28 ng/ml) regardless of the genotype of their GC gene. CONCLUSIONS: The GC gene may play a major role in determining vitamin D levels in Arab populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Vitamina D / Árabes Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Transl Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Qatar

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Vitamina D / Árabes Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Transl Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Qatar