SESOTHO trial ("Switch Either near Suppression Or THOusand") - switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa.

Amstutz, Alain; Nsakala, Bienvenu Lengo; Vanobberghen, Fiona; Muhairwe, Josephine; Glass, Tracy Renée; Achieng, Beatrice; Sepeka, Mamorena; Tlali, Katleho; Sao, Lebohang; Thin, Kyaw; Klimkait, Thomas; Battegay, Manuel; Labhardt, Niklaus Daniel

SESOTHO trial ("Switch Either near Suppression Or THOusand") - switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa.

Amstutz, Alain; Nsakala, Bienvenu Lengo; Vanobberghen, Fiona; Muhairwe, Josephine; Glass, Tracy Renée; Achieng, Beatrice; Sepeka, Mamorena; Tlali, Katleho; Sao, Lebohang; Thin, Kyaw; Klimkait, Thomas; Battegay, Manuel; Labhardt, Niklaus Daniel.

Afiliação

Amstutz A; Clinical Research Unit, Department of Medicine, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland. alain.amstutz@swisstph.ch.
Nsakala BL; University of Basel, 4051, Basel, Switzerland. alain.amstutz@swisstph.ch.
Vanobberghen F; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, 4051, Basel, Switzerland. alain.amstutz@swisstph.ch.
Muhairwe J; SolidarMed, Swiss Organization for Health in Africa, Maseru/Butha-Buthe, Lesotho.
Glass TR; Clinical Research Unit, Department of Medicine, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.
Achieng B; University of Basel, 4051, Basel, Switzerland.
Sepeka M; SolidarMed, Swiss Organization for Health in Africa, Maseru/Butha-Buthe, Lesotho.
Tlali K; Clinical Research Unit, Department of Medicine, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.
Sao L; University of Basel, 4051, Basel, Switzerland.
Thin K; SolidarMed, Swiss Organization for Health in Africa, Maseru/Butha-Buthe, Lesotho.
Klimkait T; Butha-Buthe Government Hospital, Butha-Buthe, Lesotho.
Battegay M; Butha-Buthe Government Hospital, Butha-Buthe, Lesotho.
Labhardt ND; SolidarMed, Swiss Organization for Health in Africa, Maseru/Butha-Buthe, Lesotho.

BMC Infect Dis ; 18(1): 76, 2018 02 12.

Article em En | MEDLINE | ID: mdl-29433430

Assuntos

Antirretrovirais/uso terapêutico; Infecções por HIV/tratamento farmacológico; Viremia/tratamento farmacológico; África Austral; Feminino; Guias como Assunto; Humanos; Masculino; RNA Viral/sangue; Padrão de Cuidado; Resultado do Tratamento; Carga Viral; Organização Mundial da Saúde

Palavras-chave

First-line antiretroviral therapy failure; HIV; Lesotho; Low-level viremia; Randomized controlled trial; Southern Africa; Switch to second-line antiretroviral therapy; Treatment failure; Viral suppression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viremia / Infecções por HIV / Antirretrovirais Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Qualitative_research Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça

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