Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp.
Nat Prod Res
; 33(16): 2413-2416, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-29488388
ABSTRACT
This study evaluated the hypoglycemic effect of the oil extracted from the Acrocomia aculeata pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its in vitro antioxidant and cytotoxic potential. OPAC (3, 30 or 300 mg/kg, v.o.) significantly decreased (p < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While A. aculeata oil exhibited good in vitro antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5-500 µg/mL). OPAC has antidiabetic and antioxidant activities without causing in vitro cytotoxicity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
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Arecaceae
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Citotoxinas
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Hipoglicemiantes
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Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil