[Optogenetics sheds light on memory research.Development and application of photoactivatable CaMKâ
¡ inhibitory peptide to the study of synaptic plasticity.]
Clin Calcium
; 28(3): 414-419, 2018.
Article
em Ja
| MEDLINE
| ID: mdl-29512534
ABSTRACT
In the past decade, the various types of genetically-encoded optogenetic tools using blue-light sensitive LOV2 domain have been developed and applied in a wide range of areas including neuroscience field. Recently, we succeeded in developing a photoactivatable inhibitory peptide, a genetically-encoded light inducible CaMKâ
¡ inhibitory peptide. Using this new optogenetic tool, we found that the 1 min of CaMKâ
¡ activation is sufficient for triggering structural plasticity of synapses(spines)in hippocampal neurons. Furthermore, using passive avoidance test, we found that transient CaMKâ
¡ activity, but not sustained activity, is only required for fear memory formation/maintenance in amygdala of mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina
/
Optogenética
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
Ja
Revista:
Clin Calcium
Assunto da revista:
METABOLISMO
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão