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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander W; Gretarsdottir, Solveig; Anderson, Christopher D; Chong, Michael; Adams, Hieab H H; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M; Benavente, Oscar R; Bevan, Steve; Boncoraglio, Giorgio B; Brown, Robert D; Butterworth, Adam S; Carrera, Caty; Carty, Cara L; Chasman, Daniel I; Chen, Wei-Min; Cole, John W; Correa, Adolfo; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul I W; DeStefano, Anita L; den Hoed, Marcel; Duan, Qing; Engelter, Stefan T; Falcone, Guido J; Gottesman, Rebecca F; Grewal, Raji P; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeffrey; Harris, Tamara B; Hassan, Ahamad; Havulinna, Aki S; Heckbert, Susan R; Holliday, Elizabeth G; Howard, George; Hsu, Fang-Chi.
Afiliação
  • Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Chauhan G; Centre for Brain Research, Indian Institute of Science, Bangalore, India.
  • Traylor M; INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
  • Sargurupremraj M; Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Okada Y; Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France.
  • Mishra A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Rutten-Jacobs L; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Giese AK; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
  • van der Laan SW; Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Gretarsdottir S; Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France.
  • Anderson CD; INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
  • Chong M; Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
  • Adams HHH; Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
  • Ago T; deCODE genetics/AMGEN Inc., Reykjavik, Iceland.
  • Almgren P; Center for Genomic Medicine, MGH, Boston, MA, USA.
  • Amouyel P; J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
  • Ay H; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Bartz TM; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Benavente OR; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Bevan S; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Boncoraglio GB; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Brown RD; Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Butterworth AS; INSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France.
  • Carrera C; Centre Hospitalier Université Lille, Epidemiology and Public Health Department, Lille, France.
  • Carty CL; J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
  • Chasman DI; AA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA, USA.
  • Chen WM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
  • Cole JW; Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.
  • Correa A; School of Life Science, University of Lincoln, Lincoln, UK.
  • Cotlarciuc I; Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
  • Cruchaga C; Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
  • Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • de Bakker PIW; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
  • DeStefano AL; Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain.
  • den Hoed M; Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain.
  • Duan Q; Children's Research Institute, Children's National Medical Center, Washington, DC, USA.
  • Engelter ST; Center for Translational Science, George Washington University, Washington, DC, USA.
  • Falcone GJ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Gottesman RF; Harvard Medical School, Boston, MA, USA.
  • Grewal RP; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  • Gudnason V; Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA.
  • Gustafsson S; Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
  • Haessler J; Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK.
  • Harris TB; Department of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA.
  • Hassan A; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Havulinna AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Heckbert SR; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Holliday EG; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
  • Howard G; British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK.
  • Hsu FC; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Nat Genet ; 50(4): 524-537, 2018 04.
Article em En | MEDLINE | ID: mdl-29531354
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha