In vitro immunomodulatory effects of placental substances on preparatory MLR and resulting modifications of lymphocyte reactivities.
J Reprod Immunol
; 11(3): 221-35, 1987 Jul.
Article
em En
| MEDLINE
| ID: mdl-2958627
ABSTRACT
The immunomodulatory effects of murine placental extracts (PE) were studied in vitro using mixed lymphocyte culture (MLC) and resulting cell-mediated lympholysis (CML). The results showed that preparative cultures in the presence of PE syngeneic to the responding cells led to a low secondary MLR response with a concomitant generation of suppressor cells. At the efferent phase, cells from the same preparative culture showed a weaker cytotoxic activity than controls cultured in the absence of extract. Furthermore, the induction of regulatory cells able to inhibit CTL in vitro activity was also observed. The active substances can be found in the 30% ammonium sulphate precipitate as well as in some gel filtration fractions showing several main bands from 115 to 43 kDa in SDS-PAGE.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Extratos de Tecidos
/
Linfócitos
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Reprod Immunol
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
França