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Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry.
Gilbert, Myrthe S; Ijssennagger, Noortje; Kies, Arie K; van Mil, Saskia W C.
Afiliação
  • Gilbert MS; Animal Nutrition Group, Department of Animal Sciences, Wageningen University and Research , Wageningen , The Netherlands.
  • Ijssennagger N; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands.
  • Kies AK; Animal Nutrition Group, Department of Animal Sciences, Wageningen University and Research , Wageningen , The Netherlands.
  • van Mil SWC; DSM Nutritional Products, Animal Nutrition and Health, Kaiseraugst, Switzerland.
Am J Physiol Gastrointest Liver Physiol ; 315(2): G159-G170, 2018 08 01.
Article em En | MEDLINE | ID: mdl-29597354
The amount of dietary protein is associated with intestinal disease in different vertebrate species. In humans, this is exemplified by the association between high-protein intake and fermentation metabolite concentrations in patients with inflammatory bowel disease. In production animals, dietary protein intake is associated with postweaning diarrhea in piglets and with the occurrence of wet litter in poultry. The underlying mechanisms by which dietary protein contributes to intestinal problems remain largely unknown. Fermentation of undigested protein in the hindgut results in formation of fermentation products including short-chain fatty acids, branched-chain fatty acids, ammonia, phenolic and indolic compounds, biogenic amines, hydrogen sulfide, and nitric oxide. Here, we review the mechanisms by which these metabolites may cause intestinal disease. Studies addressing how different metabolites induce epithelial damage rely mainly on cell culture studies and occasionally on mice or rat models. Often, contrasting results were reported. The direct relevance of such studies for human, pig, and poultry gut health is therefore questionable and does not suffice for the development of interventions to improve gut health. We discuss a roadmap to improve our understanding of gut metabolites and microbial species associated with intestinal health in humans and production animals and to determine whether these metabolite/bacterial networks cause epithelial damage. The outcomes of these studies will dictate proof-of-principle studies to eliminate specific metabolites and or bacterial strains and will provide the basis for interventions aiming to improve gut health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Alimentares / Trato Gastrointestinal / Enteropatias Limite: Animals / Humans Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Assunto da revista: FISIOLOGIA / GASTROENTEROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Alimentares / Trato Gastrointestinal / Enteropatias Limite: Animals / Humans Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Assunto da revista: FISIOLOGIA / GASTROENTEROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda